Research People Publications Software Links	Department of Biostatistics, Harvard School of Public Health Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute Address: Room 11028, Center for Life Sciences, 3 Blackfan Circle, Boston, MA 02115 Contact: cli@hsph.harvard.edu, 617-632-3498 (not in use temporarily) We focus on computational and statistical methods in microarray analysis of gene expression, genome alterations, and genetics, inspired by the ongoing collaborations. Genome alteration analysis using SNP arrays. · Develop methods to identify LOH and copy number changes in tumor samples with or without paired normals (ref, 2). · Integrate with other genomics data such as gene expression arrays, using myeloma samples (ref). dChip software. We are dedicated to developing and maintaining the user-friendly and free microarray analysis software dChip (manual, forum). · dChip provides many analysis and visualization methods for gene expression and SNP microarray data and has been used in many research applications. · It is the first software to perform model-based analysis of oligonucleotide expression array data and one of the first to perform copy number and LOH analysis of SNP arrays. · New analysis methods are constantly developed and tested in dChip through collaborative projects and then provided for broader use. Current research support: National Institutes of Health.